Tumor progression locus 2/Cot is required for activation of extracellular regulated kinase in liver injury and toll-like receptor-induced TIMP-1 gene transcription in hepatic stellate cells in mice.

Perugorria, Maria J; Murphy, Lindsay B; Fullard, Nicola; Chakraborty, Jayashree B; Vyrla, Dimitra; Wilson, Caroline L; Oakley, Fiona; Mann, Jelena; Mann, Derek A

Perugorria, Maria J; Murphy, Lindsay B; Fullard, Nicola; Chakraborty, Jayashree B; Vyrla, Dimitra; Wilson, Caroline L; Oakley, Fiona; Mann, Jelena; Mann, Derek A.

Affiliation

Perugorria MJ; Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

Hepatology ; 57(3): 1238-49, 2013 Mar.

Article in En | MEDLINE | ID: mdl-23080298

Subject(s)

Hepatic Stellate Cells/physiology; Liver Cirrhosis/metabolism; MAP Kinase Kinase Kinases/metabolism; MAP Kinase Signaling System/physiology; Proto-Oncogene Proteins/metabolism; Tissue Inhibitor of Metalloproteinase-1/genetics; Animals; Cells, Cultured; Cytokines/metabolism; Hepatic Stellate Cells/cytology; Hepatocytes/cytology; Hepatocytes/physiology; Kupffer Cells/cytology; Kupffer Cells/physiology; Liver Cirrhosis/genetics; Liver Cirrhosis/pathology; MAP Kinase Kinase Kinases/genetics; Macrophages/cytology; Macrophages/physiology; Male; Mice; Mice, Knockout; Proto-Oncogene Proteins/genetics; Tissue Inhibitor of Metalloproteinase-1/metabolism; Toll-Like Receptor 4/metabolism; Toll-Like Receptor 9/metabolism; Transcription, Genetic/physiology

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Full text: 1 Database: MEDLINE Main subject: Proto-Oncogene Proteins / Tissue Inhibitor of Metalloproteinase-1 / MAP Kinase Kinase Kinases / MAP Kinase Signaling System / Hepatic Stellate Cells / Liver Cirrhosis Limits: Animals Language: En Journal: Hepatology Year: 2013 Type: Article Affiliation country: United kingdom

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