Lenalidomide-mediated enhanced translation of C/EBP&#945;-p30 protein up-regulates expression of the antileukemic microRNA-181a in acute myeloid leukemia.

Hickey, Christopher J; Schwind, Sebastian; Radomska, Hanna S; Dorrance, Adrienne M; Santhanam, Ramasamy; Mishra, Anjali; Wu, Yue-Zhong; Alachkar, Houda; Maharry, Kati; Nicolet, Deedra; Mrózek, Krzysztof; Walker, Alison; Eiring, Anna M; Whitman, Susan P; Becker, Heiko; Perrotti, Danilo; Wu, Lai-Chu; Zhao, Xi; Fehniger, Todd A; Vij, Ravi; Byrd, John C; Blum, William; Lee, L James; Caligiuri, Michael A; Bloomfield, Clara D; Garzon, Ramiro; Marcucci, Guido

Lenalidomide-mediated enhanced translation of C/EBPα-p30 protein up-regulates expression of the antileukemic microRNA-181a in acute myeloid leukemia.

Hickey, Christopher J; Schwind, Sebastian; Radomska, Hanna S; Dorrance, Adrienne M; Santhanam, Ramasamy; Mishra, Anjali; Wu, Yue-Zhong; Alachkar, Houda; Maharry, Kati; Nicolet, Deedra; Mrózek, Krzysztof; Walker, Alison; Eiring, Anna M; Whitman, Susan P; Becker, Heiko; Perrotti, Danilo; Wu, Lai-Chu; Zhao, Xi; Fehniger, Todd A; Vij, Ravi; Byrd, John C; Blum, William; Lee, L James; Caligiuri, Michael A; Bloomfield, Clara D; Garzon, Ramiro; Marcucci, Guido.

Affiliation

Hickey CJ; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA.

Blood ; 121(1): 159-69, 2013 Jan 03.

Article in En | MEDLINE | ID: mdl-23100311

Subject(s)

CCAAT-Enhancer-Binding Proteins/physiology; Gene Expression Regulation, Leukemic/drug effects; Immunologic Factors/pharmacology; Leukemia, Myeloid, Acute/drug therapy; MicroRNAs/biosynthesis; Neoplasm Proteins/biosynthesis; RNA, Neoplasm/biosynthesis; Thalidomide/analogs & derivatives; Adult; Animals; Antimetabolites, Antineoplastic/pharmacology; CCAAT-Enhancer-Binding Proteins/biosynthesis; CCAAT-Enhancer-Binding Proteins/genetics; Cell Line, Tumor/drug effects; Cell Line, Tumor/metabolism; Cell Line, Tumor/transplantation; Cytarabine/pharmacology; Frameshift Mutation; Humans; Immunologic Factors/therapeutic use; K562 Cells; Lenalidomide; Leukemia, Myeloid, Acute/genetics; Leukemia, Myeloid, Acute/metabolism; Mice; Mice, Inbred NOD; Mice, SCID; MicroRNAs/genetics; Neoplasm Proteins/genetics; Point Mutation; Promoter Regions, Genetic/genetics; Protein Isoforms/biosynthesis; Protein Isoforms/genetics; Protein Isoforms/physiology; Protein Structure, Tertiary; RNA, Neoplasm/genetics; Recombinant Fusion Proteins/physiology; Thalidomide/pharmacology; Thalidomide/therapeutic use; Up-Regulation/drug effects; Xenograft Model Antitumor Assays

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Full text: 1 Database: MEDLINE Main subject: Thalidomide / RNA, Neoplasm / Leukemia, Myeloid, Acute / Gene Expression Regulation, Leukemic / CCAAT-Enhancer-Binding Proteins / MicroRNAs / Immunologic Factors / Neoplasm Proteins Type of study: Prognostic_studies Language: En Journal: Blood Year: 2013 Type: Article Affiliation country: United States

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