Mechanism of loss of Kv11.1 K+ current in mutant T421M-Kv11.1-expressing rat ventricular myocytes: interaction of trafficking and gating.

Balijepalli, Sadguna Y; Lim, Evi; Concannon, Sarah P; Chew, Chen L; Holzem, Kassandra E; Tester, David J; Ackerman, Michael J; Delisle, Brian P; Balijepalli, Ravi C; January, Craig T

Balijepalli, Sadguna Y; Lim, Evi; Concannon, Sarah P; Chew, Chen L; Holzem, Kassandra E; Tester, David J; Ackerman, Michael J; Delisle, Brian P; Balijepalli, Ravi C; January, Craig T.

Affiliation

Balijepalli SY; Department of Medicine, University of Wisconsin, Madison,WI 53792, USA.

Circulation ; 126(24): 2809-18, 2012 Dec 11.

Article in En | MEDLINE | ID: mdl-23136156

Subject(s)

Ether-A-Go-Go Potassium Channels/genetics; Ether-A-Go-Go Potassium Channels/physiology; Ion Channel Gating/physiology; Long QT Syndrome/genetics; Myocytes, Cardiac/physiology; Adult; Animals; ERG1 Potassium Channel; Female; HEK293 Cells; Humans; Long QT Syndrome/physiopathology; Membrane Potentials/physiology; Mutation, Missense/genetics; Myocytes, Cardiac/cytology; Patch-Clamp Techniques; Potassium/metabolism; Protein Transport/physiology; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta/physiology; Transfection/methods

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Full text: 1 Database: MEDLINE Main subject: Long QT Syndrome / Ion Channel Gating / Myocytes, Cardiac / Ether-A-Go-Go Potassium Channels Limits: Adult / Animals / Female / Humans Language: En Journal: Circulation Year: 2012 Type: Article Affiliation country: United States

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