Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel.

Brohawn, Stephen G; Campbell, Ernest B; MacKinnon, Roderick

Brohawn, Stephen G; Campbell, Ernest B; MacKinnon, Roderick.

Affiliation

Brohawn SG; Laboratory of Molecular Neurobiology and Biophysics and Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.

Proc Natl Acad Sci U S A ; 110(6): 2129-34, 2013 Feb 05.

Article in En | MEDLINE | ID: mdl-23341632

Subject(s)

Potassium Channels/chemistry; Antibodies, Monoclonal/chemistry; Antibodies, Monoclonal/immunology; Biophysical Phenomena; Crystallography, X-Ray; HEK293 Cells; Humans; Immunoglobulin Fab Fragments/chemistry; Immunoglobulin Fab Fragments/immunology; Ion Channel Gating; Models, Molecular; Multiprotein Complexes/chemistry; Potassium Channels/genetics; Potassium Channels/immunology; Potassium Channels/metabolism; Protein Interaction Domains and Motifs; Recombinant Proteins/chemistry; Recombinant Proteins/genetics; Recombinant Proteins/immunology; Recombinant Proteins/metabolism

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Full text: 1 Database: MEDLINE Main subject: Potassium Channels Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2013 Type: Article Affiliation country: United States

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