Vitronectin inhibits efferocytosis through interactions with apoptotic cells as well as with macrophages.

Bae, Hong-Beom; Tadie, Jean-Marc; Jiang, Shaoning; Park, Dae Won; Bell, Celeste P; Thompson, Lawrence C; Peterson, Cynthia B; Thannickal, Victor J; Abraham, Edward; Zmijewski, Jaroslaw W

Bae, Hong-Beom; Tadie, Jean-Marc; Jiang, Shaoning; Park, Dae Won; Bell, Celeste P; Thompson, Lawrence C; Peterson, Cynthia B; Thannickal, Victor J; Abraham, Edward; Zmijewski, Jaroslaw W.

Affiliation

Bae HB; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294-0012, USA.

J Immunol ; 190(5): 2273-81, 2013 Mar 01.

Article in En | MEDLINE | ID: mdl-23345331

Subject(s)

Acute Lung Injury/immunology; Apoptosis/drug effects; Macrophages, Peritoneal/drug effects; Neutrophils/drug effects; Phagocytosis/drug effects; Thymocytes/drug effects; Vitronectin/immunology; Acute Lung Injury/chemically induced; Acute Lung Injury/metabolism; Acute Lung Injury/pathology; Animals; Antibodies/pharmacology; Apoptosis/immunology; Bronchoalveolar Lavage Fluid/chemistry; Bronchoalveolar Lavage Fluid/immunology; Cell Count; Coculture Techniques; Female; Lipopolysaccharides; Macrophages, Peritoneal/immunology; Macrophages, Peritoneal/pathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils/immunology; Neutrophils/pathology; Phagocytosis/immunology; Plasminogen Activator Inhibitor 1/pharmacology; Receptors, Urokinase Plasminogen Activator/antagonists & inhibitors; Receptors, Urokinase Plasminogen Activator/genetics; Receptors, Urokinase Plasminogen Activator/immunology; Thymocytes/immunology; Thymocytes/pathology; Vitronectin/deficiency; Vitronectin/genetics

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Full text: 1 Database: MEDLINE Main subject: Phagocytosis / Apoptosis / Macrophages, Peritoneal / Vitronectin / Acute Lung Injury / Thymocytes / Neutrophils Limits: Animals Language: En Journal: J Immunol Year: 2013 Type: Article Affiliation country: United States

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