A novel neurofibromin (NF1) interaction with the leucine-rich pentatricopeptide repeat motif-containing protein links neurofibromatosis type 1 and the French Canadian variant of Leigh's syndrome in a common molecular complex.

Arun, Vedant; Wiley, Joseph C; Kaur, Harpreet; Kaplan, David R; Guha, Abhijit

Arun, Vedant; Wiley, Joseph C; Kaur, Harpreet; Kaplan, David R; Guha, Abhijit.

Affiliation

Arun V; The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada.

J Neurosci Res ; 91(4): 494-505, 2013 Apr.

Article in En | MEDLINE | ID: mdl-23361976

Subject(s)

Cytochrome-c Oxidase Deficiency/metabolism; Leigh Disease/metabolism; Mitochondrial Proteins/metabolism; Neurofibromatosis 1/metabolism; Neurofibromin 1/metabolism; Cell Line, Tumor; Cytochrome-c Oxidase Deficiency/genetics; Humans; Leigh Disease/genetics; Mitochondrial Proteins/genetics; Mutation; Neurofibromatosis 1/genetics; Neurofibromin 1/genetics; Protein Structure, Tertiary; Schwann Cells/metabolism; ras GTPase-Activating Proteins/genetics; ras GTPase-Activating Proteins/metabolism

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Full text: 1 Database: MEDLINE Main subject: Leigh Disease / Neurofibromatosis 1 / Cytochrome-c Oxidase Deficiency / Neurofibromin 1 / Mitochondrial Proteins Limits: Humans Language: En Journal: J Neurosci Res Year: 2013 Type: Article Affiliation country: Canada

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