EBV counteracts IL-21-induced apoptosis in an EBV-positive diffuse large B-cell lymphoma cell line.
Int J Cancer
; 133(3): 766-70, 2013 Aug 01.
Article
in En
| MEDLINE
| ID: mdl-23364893
ABSTRACT
Previously, interleukin (IL)-21 has been found to induce apoptosis by activating the signal transducer and activator of transcription 3 (STAT3) and concomitant upregulation of c-Myc in diffuse large B-cell lymphoma (DLBCL) lines with unknown Epstein-Barr virus (EBV) status. Here, as a first approach toward the characterization of the role of EBV in DLCBL, the EBV gene expression and the IL-21 sensitivity of the EBV-positive DLBCL line, Farage, have been examined. It was found that, surprisingly, despite c-Myc upregulation, IL-21 induced cell proliferation rather than apoptosis in Farage. Expression of a dominant-negative EBNA1 mutant and the consecutive downregulation of EBV gene expression antagonized the IL-21-induced proliferation of Farage and increased apoptosis. These findings reveal a previously unknown role of EBV in DLBCL that is of possible relevance for the current attempt to use IL-21 in therapy.
Full text:
1
Database:
MEDLINE
Main subject:
Lymphoma, Large B-Cell, Diffuse
/
Interleukins
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Apoptosis
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Herpesvirus 4, Human
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Epstein-Barr Virus Nuclear Antigens
Limits:
Humans
Language:
En
Journal:
Int J Cancer
Year:
2013
Type:
Article
Affiliation country:
Sweden