MSK1 and MSK2 inhibit lipopolysaccharide-induced prostaglandin production via an interleukin-10 feedback loop.

MacKenzie, Kirsty F; Van Den Bosch, Mirjam W M; Naqvi, Shaista; Elcombe, Suzanne E; McGuire, Victoria A; Reith, Alastair D; Blackshear, Perry J; Dean, Jonathan L E; Arthur, J Simon C

MacKenzie, Kirsty F; Van Den Bosch, Mirjam W M; Naqvi, Shaista; Elcombe, Suzanne E; McGuire, Victoria A; Reith, Alastair D; Blackshear, Perry J; Dean, Jonathan L E; Arthur, J Simon C.

Affiliation

MacKenzie KF; MRC Protein Phosphorylation Unit, Sir James Black Complex, School of Life Sciences, University of Dundee, Dundee, United Kingdom.

Mol Cell Biol ; 33(7): 1456-67, 2013 Apr.

Article in En | MEDLINE | ID: mdl-23382072

Subject(s)

Interleukin-10/metabolism; Lipopolysaccharides/pharmacology; Prostaglandins/metabolism; Ribosomal Protein S6 Kinases, 90-kDa/metabolism; Adaptor Proteins, Signal Transducing/genetics; Adaptor Proteins, Signal Transducing/metabolism; Animals; Cells, Cultured; Cyclooxygenase 2/genetics; Cyclooxygenase 2/metabolism; Interleukin-10/genetics; Intracellular Signaling Peptides and Proteins/genetics; Intracellular Signaling Peptides and Proteins/metabolism; Macrophages; Mice; Mice, Inbred C57BL; Prostaglandins/genetics; Protein Serine-Threonine Kinases/genetics; Protein Serine-Threonine Kinases/metabolism; Proteolysis; RNA Stability; RNA, Messenger/genetics; Ribosomal Protein S6 Kinases, 90-kDa/genetics; Toll-Like Receptors/agonists; Toll-Like Receptors/genetics; Toll-Like Receptors/metabolism; Transcription, Genetic; p38 Mitogen-Activated Protein Kinases/genetics; p38 Mitogen-Activated Protein Kinases/metabolism

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Full text: 1 Database: MEDLINE Main subject: Prostaglandins / Lipopolysaccharides / Interleukin-10 / Ribosomal Protein S6 Kinases, 90-kDa Limits: Animals Language: En Journal: Mol Cell Biol Year: 2013 Type: Article Affiliation country: United kingdom

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