Combined ChIP-Seq and transcriptome analysis identifies AP-1/JunD as a primary regulator of oxidative stress and IL-1ß synthesis in macrophages.

Hull, Richard P; Srivastava, Prashant K; D'Souza, Zelpha; Atanur, Santosh S; Mechta-Grigoriou, Fatima; Game, Laurence; Petretto, Enrico; Cook, H Terence; Aitman, Timothy J; Behmoaras, Jacques

Hull, Richard P; Srivastava, Prashant K; D'Souza, Zelpha; Atanur, Santosh S; Mechta-Grigoriou, Fatima; Game, Laurence; Petretto, Enrico; Cook, H Terence; Aitman, Timothy J; Behmoaras, Jacques.

Affiliation

Hull RP; MRC Clinical Sciences Centre, Imperial College London, Hammersmithhospital, Du Cane Road W12 0NN, London, UK.

BMC Genomics ; 14: 92, 2013 Feb 11.

Article in En | MEDLINE | ID: mdl-23398888

Subject(s)

Interleukin-1beta/metabolism; Macrophages/metabolism; Oxidative Stress/genetics; Proto-Oncogene Proteins c-jun; Transcription Factor AP-1; Animals; Binding Sites; Gene Expression/drug effects; Gene Expression Profiling; Glomerulonephritis/chemically induced; Glomerulonephritis/genetics; Glomerulonephritis/metabolism; Glomerulonephritis/pathology; Interleukin-1beta/biosynthesis; Interleukin-1beta/genetics; Lipopolysaccharides/toxicity; Macrophages/cytology; Macrophages/drug effects; Primary Cell Culture; Protein Binding; Proto-Oncogene Proteins c-jun/genetics; Proto-Oncogene Proteins c-jun/metabolism; Rats; Transcription Factor AP-1/genetics; Transcription Factor AP-1/metabolism

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Full text: 1 Database: MEDLINE Main subject: Proto-Oncogene Proteins c-jun / Transcription Factor AP-1 / Oxidative Stress / Interleukin-1beta / Macrophages Type of study: Prognostic_studies Limits: Animals Language: En Journal: BMC Genomics Journal subject: GENETICA Year: 2013 Type: Article Affiliation country: United kingdom

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