Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors.

Raman, Kavita; Trivedi, Neil N; Raymond, Wilfred W; Ganesan, Rajkumar; Kirchhofer, Daniel; Verghese, George M; Craik, Charles S; Schneider, Eric L; Nimishakavi, Shilpa; Caughey, George H

Raman, Kavita; Trivedi, Neil N; Raymond, Wilfred W; Ganesan, Rajkumar; Kirchhofer, Daniel; Verghese, George M; Craik, Charles S; Schneider, Eric L; Nimishakavi, Shilpa; Caughey, George H.

Affiliation

Raman K; Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA.

J Biol Chem ; 288(15): 10588-98, 2013 Apr 12.

Article in En | MEDLINE | ID: mdl-23447538

Subject(s)

Evolution, Molecular; Membrane Proteins/genetics; Membrane Proteins/metabolism; Serine Endopeptidases/genetics; Serine Endopeptidases/metabolism; Animals; CHO Cells; Cattle; Cricetinae; Cricetulus; Guinea Pigs; Humans; Membrane Proteins/antagonists & inhibitors; Mice; Mice, Mutant Strains; Mole Rats; Mutation; Pan paniscus; Pan troglodytes; Protease Inhibitors/pharmacology; Rats; Solubility; Species Specificity

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Full text: 1 Database: MEDLINE Main subject: Serine Endopeptidases / Evolution, Molecular / Membrane Proteins Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2013 Type: Article Affiliation country: United States

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