Selective killing of candidate AML stem cells by antibody targeting of IL1RAP.

Askmyr, Maria; Ågerstam, Helena; Hansen, Nils; Gordon, Sandra; Arvanitakis, Alexandros; Rissler, Marianne; Juliusson, Gunnar; Richter, Johan; Järås, Marcus; Fioretos, Thoas

Askmyr, Maria; Ågerstam, Helena; Hansen, Nils; Gordon, Sandra; Arvanitakis, Alexandros; Rissler, Marianne; Juliusson, Gunnar; Richter, Johan; Järås, Marcus; Fioretos, Thoas.

Affiliation

Askmyr M; Department of Clinical Genetics, University and Regional Laboratories, Lund University, Lund, Sweden.

Blood ; 121(18): 3709-13, 2013 May 02.

Article in En | MEDLINE | ID: mdl-23479569

Subject(s)

Antibodies/pharmacology; Cytotoxicity, Immunologic/drug effects; Interleukin-1 Receptor Accessory Protein/immunology; Leukemia, Myeloid, Acute/pathology; Neoplastic Stem Cells/drug effects; Neoplastic Stem Cells/immunology; Adult; Aged; Aged, 80 and over; Antibody Specificity; Cells, Cultured; Female; Humans; Immunotherapy/methods; Interleukin-1 Receptor Accessory Protein/antagonists & inhibitors; Male; Middle Aged; Molecular Targeted Therapy; Neoplastic Stem Cells/pathology

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Full text: 1 Database: MEDLINE Main subject: Neoplastic Stem Cells / Leukemia, Myeloid, Acute / Cytotoxicity, Immunologic / Interleukin-1 Receptor Accessory Protein / Antibodies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Blood Year: 2013 Type: Article Affiliation country: Sweden

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