Curcumin ameliorates the permeability of the blood-brain barrier during hypoxia by upregulating heme oxygenase-1 expression in brain microvascular endothelial cells.

Wang, Yan-feng; Gu, Yan-ting; Qin, Guang-hua; Zhong, Lei; Meng, Ying-nan

Wang, Yan-feng; Gu, Yan-ting; Qin, Guang-hua; Zhong, Lei; Meng, Ying-nan.

Affiliation

Wang YF; Department of Orthopaedics, The First Affiliated Hospital, China Medical University, Beier Road No. 92, HePing District, Shenyang, 110001, Liaoning Province, People's Republic of China, wangyanfeng793@yahoo.com.cn.

J Mol Neurosci ; 51(2): 344-51, 2013 Oct.

Article in En | MEDLINE | ID: mdl-23494637

Subject(s)

Blood-Brain Barrier/drug effects; Capillary Permeability/drug effects; Cell Hypoxia; Curcumin/pharmacology; Endothelial Cells/drug effects; Heme Oxygenase-1/metabolism; Up-Regulation; Animals; Brain/blood supply; Cells, Cultured; Endothelial Cells/metabolism; Endothelium, Vascular/cytology; Endothelium, Vascular/drug effects; Endothelium, Vascular/metabolism; Glucose/metabolism; Heme Oxygenase-1/antagonists & inhibitors; Heme Oxygenase-1/genetics; Microvessels/cytology; Oxygen/metabolism; Protoporphyrins/pharmacology; Rats; Tight Junction Proteins/genetics; Tight Junction Proteins/metabolism

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Full text: 1 Database: MEDLINE Main subject: Capillary Permeability / Blood-Brain Barrier / Cell Hypoxia / Up-Regulation / Curcumin / Endothelial Cells / Heme Oxygenase-1 Limits: Animals Language: En Journal: J Mol Neurosci Journal subject: BIOLOGIA MOLECULAR / NEUROLOGIA Year: 2013 Type: Article

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