Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome.

Misawa, Takuma; Takahama, Michihiro; Kozaki, Tatsuya; Lee, Hanna; Zou, Jian; Saitoh, Tatsuya; Akira, Shizuo

Misawa, Takuma; Takahama, Michihiro; Kozaki, Tatsuya; Lee, Hanna; Zou, Jian; Saitoh, Tatsuya; Akira, Shizuo.

Affiliation

Misawa T; Laboratory of Host Defense, World Premier International Research Center Immunology Frontier Research Center, Osaka University, Osaka, Japan.

Nat Immunol ; 14(5): 454-60, 2013 May.

Article in En | MEDLINE | ID: mdl-23502856

Subject(s)

Carrier Proteins/metabolism; Cytoskeletal Proteins/metabolism; Endoplasmic Reticulum/metabolism; Inflammasomes/metabolism; Mitochondria/physiology; Acetylation; Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins/immunology; Cell Line; Cytoplasmic Streaming; Cytoskeletal Proteins/genetics; Dyneins/metabolism; Female; Mice; Mice, Inbred C57BL; Microtubules/metabolism; NAD/metabolism; NLR Family, Pyrin Domain-Containing 3 Protein; Signal Transduction; Sirtuin 2/metabolism; Tubulin/chemistry; Tubulin/metabolism

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Full text: 1 Database: MEDLINE Main subject: Carrier Proteins / Cytoskeletal Proteins / Endoplasmic Reticulum / Inflammasomes / Mitochondria Limits: Animals Language: En Journal: Nat Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2013 Type: Article Affiliation country: Japan

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