Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection.

Lupfer, Christopher; Thomas, Paul G; Anand, Paras K; Vogel, Peter; Milasta, Sandra; Martinez, Jennifer; Huang, Gonghua; Green, Maggie; Kundu, Mondira; Chi, Hongbo; Xavier, Ramnik J; Green, Douglas R; Lamkanfi, Mohamed; Dinarello, Charles A; Doherty, Peter C; Kanneganti, Thirumala-Devi

Lupfer, Christopher; Thomas, Paul G; Anand, Paras K; Vogel, Peter; Milasta, Sandra; Martinez, Jennifer; Huang, Gonghua; Green, Maggie; Kundu, Mondira; Chi, Hongbo; Xavier, Ramnik J; Green, Douglas R; Lamkanfi, Mohamed; Dinarello, Charles A; Doherty, Peter C; Kanneganti, Thirumala-Devi.

Affiliation

Lupfer C; Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

Nat Immunol ; 14(5): 480-8, 2013 May.

Article in En | MEDLINE | ID: mdl-23525089

Subject(s)

Alphainfluenzavirus/immunology; Carrier Proteins/metabolism; Inflammasomes/metabolism; Mitochondria/physiology; Mitophagy; Orthomyxoviridae Infections/immunology; Receptor-Interacting Protein Serine-Threonine Kinase 2/metabolism; Animals; Autophagy-Related Protein-1 Homolog; Caspase 1/metabolism; Cells, Cultured; Immunity, Active/genetics; Interleukin-18/metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; NLR Family, Pyrin Domain-Containing 3 Protein; Nod2 Signaling Adaptor Protein/genetics; Nod2 Signaling Adaptor Protein/metabolism; Protein Serine-Threonine Kinases/genetics; Protein Serine-Threonine Kinases/metabolism; Receptor-Interacting Protein Serine-Threonine Kinase 2/genetics; Signal Transduction/genetics; Superoxides/metabolism; Virulence Factors/genetics

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Full text: 1 Database: MEDLINE Main subject: Carrier Proteins / Orthomyxoviridae Infections / Alphainfluenzavirus / Receptor-Interacting Protein Serine-Threonine Kinase 2 / Inflammasomes / Mitophagy / Mitochondria Limits: Animals Language: En Journal: Nat Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2013 Type: Article Affiliation country: United States

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