Increased muscle force production and bone mineral density in ActRIIB-Fc-treated mature rodents.

Chiu, Chi-Sung; Peekhaus, Norbert; Weber, Hans; Adamski, Sharon; Murray, Edward M; Zhang, Hai Zhuan; Zhao, Jing Zhang; Ernst, Robin; Lineberger, Janet; Huang, Lingyi; Hampton, Richard; Arnold, Beth Anne; Vitelli, Salvatore; Hamuro, Lora; Wang, Wei-Rong; Wei, Nan; Dillon, Greg M; Miao, Jiangyong; Alves, Stephen E; Glantschnig, Helmut; Wang, Fubao; Wilkinson, Hilary A

Chiu, Chi-Sung; Peekhaus, Norbert; Weber, Hans; Adamski, Sharon; Murray, Edward M; Zhang, Hai Zhuan; Zhao, Jing Zhang; Ernst, Robin; Lineberger, Janet; Huang, Lingyi; Hampton, Richard; Arnold, Beth Anne; Vitelli, Salvatore; Hamuro, Lora; Wang, Wei-Rong; Wei, Nan; Dillon, Greg M; Miao, Jiangyong; Alves, Stephen E; Glantschnig, Helmut; Wang, Fubao; Wilkinson, Hilary A.

Affiliation

Chiu CS; Merck Research Laboratories, 126 E Lincoln Ave., RY80T-A100, Rahway, NJ 07065. hilary.wilkinson@merck.com.

J Gerontol A Biol Sci Med Sci ; 68(10): 1181-92, 2013 Oct.

Article in En | MEDLINE | ID: mdl-23525481

Subject(s)

Activin Receptors, Type II/pharmacology; Aging/drug effects; Aging/physiology; Bone Density/drug effects; Muscle Contraction/drug effects; Activin Receptors, Type II/metabolism; Animals; Biomarkers/blood; Bone Density/physiology; Cell Line; HEK293 Cells; Humans; Immunoglobulin Fc Fragments/metabolism; Immunoglobulin Fc Fragments/pharmacology; Male; Mice; Mice, Inbred C57BL; Muscle Contraction/physiology; Muscle Strength/drug effects; Muscle Strength/physiology; Myostatin/metabolism; Orchiectomy; Peptide Fragments/blood; Procollagen/blood; Recombinant Fusion Proteins/metabolism; Recombinant Fusion Proteins/pharmacology; Sarcopenia/drug therapy; Sarcopenia/pathology; Sarcopenia/physiopathology

Key words

Activin receptor type IIB; Muscle; Myostatin; Sarcopenia

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Full text: 1 Database: MEDLINE Main subject: Aging / Bone Density / Activin Receptors, Type II / Muscle Contraction Limits: Animals / Humans / Male Language: En Journal: J Gerontol A Biol Sci Med Sci Journal subject: GERIATRIA Year: 2013 Type: Article

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