Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker.

Yan, Qingrong; Barros, Tiago; Visperas, Patrick R; Deindl, Sebastian; Kadlecek, Theresa A; Weiss, Arthur; Kuriyan, John

Yan, Qingrong; Barros, Tiago; Visperas, Patrick R; Deindl, Sebastian; Kadlecek, Theresa A; Weiss, Arthur; Kuriyan, John.

Affiliation

Yan Q; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.

Mol Cell Biol ; 33(11): 2188-201, 2013 Jun.

Article in En | MEDLINE | ID: mdl-23530057

Subject(s)

ZAP-70 Protein-Tyrosine Kinase/chemistry; ZAP-70 Protein-Tyrosine Kinase/metabolism; Adaptor Proteins, Signal Transducing/genetics; Adaptor Proteins, Signal Transducing/metabolism; Crystallography, X-Ray; Fluorescence Resonance Energy Transfer; GRB2 Adaptor Protein/genetics; GRB2 Adaptor Protein/metabolism; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Intracellular Signaling Peptides and Proteins/chemistry; Intracellular Signaling Peptides and Proteins/metabolism; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/genetics; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism; Membrane Proteins/genetics; Membrane Proteins/metabolism; Models, Molecular; Phosphorylation; Protein Conformation; Protein Structure, Tertiary; Protein-Tyrosine Kinases/chemistry; Protein-Tyrosine Kinases/metabolism; Syk Kinase; Tyrosine/chemistry; Tyrosine/metabolism; ZAP-70 Protein-Tyrosine Kinase/genetics; src Homology Domains; src-Family Kinases/chemistry; src-Family Kinases/metabolism

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Full text: 1 Database: MEDLINE Main subject: ZAP-70 Protein-Tyrosine Kinase Type of study: Prognostic_studies Limits: Humans Language: En Journal: Mol Cell Biol Year: 2013 Type: Article Affiliation country: United States

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