Succinate is an inflammatory signal that induces IL-1ß through HIF-1&#945;.

Tannahill, G M; Curtis, A M; Adamik, J; Palsson-McDermott, E M; McGettrick, A F; Goel, G; Frezza, C; Bernard, N J; Kelly, B; Foley, N H; Zheng, L; Gardet, A; Tong, Z; Jany, S S; Corr, S C; Haneklaus, M; Caffrey, B E; Pierce, K; Walmsley, S; Beasley, F C; Cummins, E; Nizet, V; Whyte, M; Taylor, C T; Lin, H; Masters, S L; Gottlieb, E; Kelly, V P; Clish, C; Auron, P E; Xavier, R J; O'Neill, L A J

Succinate is an inflammatory signal that induces IL-1ß through HIF-1α.

Tannahill, G M; Curtis, A M; Adamik, J; Palsson-McDermott, E M; McGettrick, A F; Goel, G; Frezza, C; Bernard, N J; Kelly, B; Foley, N H; Zheng, L; Gardet, A; Tong, Z; Jany, S S; Corr, S C; Haneklaus, M; Caffrey, B E; Pierce, K; Walmsley, S; Beasley, F C; Cummins, E; Nizet, V; Whyte, M; Taylor, C T; Lin, H; Masters, S L; Gottlieb, E; Kelly, V P; Clish, C; Auron, P E; Xavier, R J; O'Neill, L A J.

Affiliation

Tannahill GM; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.

Nature ; 496(7444): 238-42, 2013 Apr 11.

Article in En | MEDLINE | ID: mdl-23535595

Subject(s)

Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Interleukin-1beta/biosynthesis; Signal Transduction; Succinic Acid/metabolism; Animals; Bone Marrow Cells/cytology; Citric Acid Cycle/drug effects; Deoxyglucose/pharmacology; Down-Regulation/drug effects; Genes, Mitochondrial/drug effects; Genes, Mitochondrial/genetics; Glutamine/metabolism; Glycolysis/drug effects; Glycolysis/genetics; Humans; Immunity, Innate/drug effects; Inflammation/metabolism; Interleukin-1beta/genetics; Lipopolysaccharides/pharmacology; Macrophages/cytology; Macrophages/drug effects; Macrophages/metabolism; Mice; Up-Regulation/drug effects; gamma-Aminobutyric Acid/metabolism

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Full text: 1 Database: MEDLINE Main subject: Signal Transduction / Succinic Acid / Hypoxia-Inducible Factor 1, alpha Subunit / Interleukin-1beta Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nature Year: 2013 Type: Article Affiliation country: Ireland

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