Carrier Proteins/physiology; MAP Kinase Kinase Kinases/metabolism; Neovascularization, Physiologic/genetics; Protein Serine-Threonine Kinases/physiology; Transforming Growth Factor beta/metabolism; Adherens Junctions/enzymology; Adherens Junctions/ultrastructure; Amino Acid Sequence; Animals; Carrier Proteins/chemistry; Cell Proliferation; Conserved Sequence; Embryonic Development/genetics; Gene Expression Regulation, Developmental; HEK293 Cells; Human Umbilical Vein Endothelial Cells/enzymology; Humans; MADS Domain Proteins/metabolism; MEF2 Transcription Factors; Matrix Metalloproteinase 10/genetics; Matrix Metalloproteinase 10/metabolism; Mice; Mice, Knockout; Molecular Sequence Data; Myogenic Regulatory Factors/metabolism; Phosphorylation; Protein Interaction Mapping; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases/chemistry; Proteolysis; Signal Transduction; Vascular Endothelial Growth Factor A/genetics; Vascular Endothelial Growth Factor A/metabolism