Deficiency of ATP-binding cassette transporters A1 and G1 in macrophages increases inflammation and accelerates atherosclerosis in mice.

Westerterp, Marit; Murphy, Andrew J; Wang, Mi; Pagler, Tamara A; Vengrenyuk, Yuliya; Kappus, Mojdeh S; Gorman, Darren J; Nagareddy, Prabhakara R; Zhu, Xuewei; Abramowicz, Sandra; Parks, John S; Welch, Carrie; Fisher, Edward A; Wang, Nan; Yvan-Charvet, Laurent; Tall, Alan R

Westerterp, Marit; Murphy, Andrew J; Wang, Mi; Pagler, Tamara A; Vengrenyuk, Yuliya; Kappus, Mojdeh S; Gorman, Darren J; Nagareddy, Prabhakara R; Zhu, Xuewei; Abramowicz, Sandra; Parks, John S; Welch, Carrie; Fisher, Edward A; Wang, Nan; Yvan-Charvet, Laurent; Tall, Alan R.

Affiliation

Westerterp M; Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA. mw2537@columbia.edu

Circ Res ; 112(11): 1456-65, 2013 May 24.

Article in En | MEDLINE | ID: mdl-23572498

Subject(s)

ATP-Binding Cassette Transporters/genetics; ATP-Binding Cassette Transporters/immunology; Atherosclerosis/immunology; Lipoproteins/genetics; Lipoproteins/immunology; Vasculitis/immunology; ATP Binding Cassette Transporter 1; ATP Binding Cassette Transporter, Subfamily G, Member 1; ATP-Binding Cassette Transporters/metabolism; Animal Feed; Animals; Atherosclerosis/genetics; Atherosclerosis/pathology; Bone Marrow Transplantation; Cholesterol, Dietary/metabolism; Foam Cells/immunology; Foam Cells/metabolism; Foam Cells/pathology; Lipoproteins/metabolism; Macrophages/immunology; Macrophages/metabolism; Macrophages/pathology; Mice; Mice, Knockout; Monocytes/immunology; Monocytes/metabolism; Monocytes/pathology; Neutrophils/immunology; Neutrophils/metabolism; Neutrophils/pathology; Receptors, LDL/genetics; Receptors, LDL/metabolism; Spleen/pathology; Vasculitis/genetics; Vasculitis/pathology

Key words

atherosclerosis; high-density lipoprotein; inflammation; macrophages; monocytes

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Full text: 1 Database: MEDLINE Main subject: Vasculitis / ATP-Binding Cassette Transporters / Atherosclerosis / Lipoproteins Limits: Animals Language: En Journal: Circ Res Year: 2013 Type: Article Affiliation country: United States

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