Transgenic mouse &#945;- and ß-cardiac myosins containing the R403Q mutation show isoform-dependent transient kinetic differences.

Lowey, Susan; Bretton, Vera; Gulick, James; Robbins, Jeffrey; Trybus, Kathleen M

Transgenic mouse α- and ß-cardiac myosins containing the R403Q mutation show isoform-dependent transient kinetic differences.

Lowey, Susan; Bretton, Vera; Gulick, James; Robbins, Jeffrey; Trybus, Kathleen M.

Affiliation

Lowey S; Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont 05405, USA. susan.lowey@uvm.edu

J Biol Chem ; 288(21): 14780-7, 2013 May 24.

Article in En | MEDLINE | ID: mdl-23580644

Subject(s)

Adenosine Diphosphate/metabolism; Mutation, Missense; Myosin Heavy Chains/metabolism; Ventricular Myosins/metabolism; Adenosine Diphosphate/genetics; Amino Acid Substitution; Animals; Kinetics; Mice; Mice, Transgenic; Myosin Heavy Chains/genetics; Protein Binding/genetics; Ventricular Myosins/genetics

Key words

Cardiac Myosin Isoforms; Cardiomyopathy; Cardiovascular Disease; Familial Hypertrophic Cardiomyopathy; Kinetics; Myosin; Myosin Heavy Chain Mutations; Transgenic Mice; Transient Kinetics

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Full text: 1 Database: MEDLINE Main subject: Adenosine Diphosphate / Myosin Heavy Chains / Mutation, Missense / Ventricular Myosins Limits: Animals Language: En Journal: J Biol Chem Year: 2013 Type: Article Affiliation country: United States

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