TCR triggering modulates the responsiveness and homeostatic proliferation of CD4+ thymic emigrants to IL-7 therapy.

Hennion-Tscheltzoff, Olga; Leboeuf, Dominique; Gauthier, Simon-David; Dupuis, Martine; Assouline, Brigitte; Grégoire, Anne; Thiant, Stéphanie; Guimond, Martin

Hennion-Tscheltzoff, Olga; Leboeuf, Dominique; Gauthier, Simon-David; Dupuis, Martine; Assouline, Brigitte; Grégoire, Anne; Thiant, Stéphanie; Guimond, Martin.

Affiliation

Hennion-Tscheltzoff O; Maisonneuve-Rosemont Hospital Research Center, Montreal, QC, Canada.

Blood ; 121(23): 4684-93, 2013 Jun 06.

Article in En | MEDLINE | ID: mdl-23613523

Subject(s)

CD4-Positive T-Lymphocytes/immunology; CD8-Positive T-Lymphocytes/immunology; Interleukin-7/administration & dosage; Lymphopenia/immunology; Receptors, Antigen, T-Cell/metabolism; Thymus Gland/immunology; Animals; CD4-Positive T-Lymphocytes/cytology; CD4-Positive T-Lymphocytes/drug effects; CD8-Positive T-Lymphocytes/cytology; CD8-Positive T-Lymphocytes/drug effects; Cells, Cultured; Flow Cytometry; Homeodomain Proteins/physiology; Homeostasis; Interleukin-7/pharmacology; Lymphocyte Activation; Lymphopenia/metabolism; Lymphopenia/pathology; Mice; Mice, Inbred C57BL; MicroRNAs/genetics; Proto-Oncogene Proteins c-bcl-2/genetics; Proto-Oncogene Proteins c-bcl-2/metabolism; Real-Time Polymerase Chain Reaction; Receptors, Antigen, T-Cell/genetics; STAT5 Transcription Factor/genetics; STAT5 Transcription Factor/metabolism; Thymus Gland/cytology; Thymus Gland/drug effects

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Full text: 1 Database: MEDLINE Main subject: Thymus Gland / Receptors, Antigen, T-Cell / CD4-Positive T-Lymphocytes / Interleukin-7 / CD8-Positive T-Lymphocytes / Lymphopenia Limits: Animals Language: En Journal: Blood Year: 2013 Type: Article Affiliation country: Canada

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