Splicing kinetics and transcript release from the chromatin compartment limit the rate of Lipid A-induced gene expression.

Pandya-Jones, Amy; Bhatt, Dev M; Lin, Chia-Ho; Tong, Ann-Jay; Smale, Stephen T; Black, Douglas L

Pandya-Jones, Amy; Bhatt, Dev M; Lin, Chia-Ho; Tong, Ann-Jay; Smale, Stephen T; Black, Douglas L.

Affiliation

Pandya-Jones A; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California 90025, USA.

RNA ; 19(6): 811-27, 2013 Jun.

Article in En | MEDLINE | ID: mdl-23616639

Subject(s)

Alternative Splicing; Lipid A/pharmacology; Macrophages/drug effects; RNA, Messenger/metabolism; Animals; Cell Nucleus/genetics; Cell Nucleus/metabolism; Chromatin/genetics; Chromatin/metabolism; Exons; Gene Expression Regulation; Inflammation/genetics; Introns; Macrophages/cytology; Macrophages/metabolism; Mice; Mice, Inbred C57BL; Polyadenylation; RNA Cleavage; RNA Splice Sites; RNA, Messenger/genetics; Time Factors; Transcription, Genetic

Key words

gene expression; inflammatory response; mRNA maturation; pre-mRNA splicing; splicing kinetics

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Full text: 1 Database: MEDLINE Main subject: RNA, Messenger / Alternative Splicing / Lipid A / Macrophages Limits: Animals Language: En Journal: RNA Journal subject: BIOLOGIA MOLECULAR Year: 2013 Type: Article Affiliation country: United States

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