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Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): a potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery.
Chaturvedula, Prasad V; Mercer, Stephen E; Pin, Sokhom S; Thalody, George; Xu, Cen; Conway, Charlie M; Keavy, Deborah; Signor, Laura; Cantor, Glenn H; Mathias, Neil; Moench, Paul; Denton, Rex; Macci, Robert; Schartman, Richard; Whiterock, Valerie; Davis, Carl; Macor, John E; Dubowchik, Gene M.
Affiliation
  • Chaturvedula PV; Department of Molecular Sciences and Candidate Optimization, Bristol-Myers Squibb R&D, 5 Research Parkway, Wallingford, CT 06492, USA. Prasad.Chaturvedula@bms.com
Bioorg Med Chem Lett ; 23(11): 3157-61, 2013 Jun 01.
Article in En | MEDLINE | ID: mdl-23632269
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Full text: 1 Database: MEDLINE Main subject: Quinolones / Calcitonin Gene-Related Peptide Receptor Antagonists / Amides / Indazoles Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2013 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Quinolones / Calcitonin Gene-Related Peptide Receptor Antagonists / Amides / Indazoles Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2013 Type: Article Affiliation country: United States