Overexpression of angiopoietin-like protein 4 protects against atherosclerosis development.

Georgiadi, Anastasia; Wang, Yanan; Stienstra, Rinke; Tjeerdema, Nathanja; Janssen, Aafke; Stalenhoef, Anton; van der Vliet, J Adam; de Roos, Albert; Tamsma, Jouke T; Smit, Johannes W A; Tan, Nguan Soon; Müller, Michael; Rensen, Patrick C N; Kersten, Sander

Georgiadi, Anastasia; Wang, Yanan; Stienstra, Rinke; Tjeerdema, Nathanja; Janssen, Aafke; Stalenhoef, Anton; van der Vliet, J Adam; de Roos, Albert; Tamsma, Jouke T; Smit, Johannes W A; Tan, Nguan Soon; Müller, Michael; Rensen, Patrick C N; Kersten, Sander.

Affiliation

Georgiadi A; Nutrition, Metabolism, and Genomics Group, Wageningen University, Wageningen, The Netherlands.

Arterioscler Thromb Vasc Biol ; 33(7): 1529-37, 2013 Jul.

Article in En | MEDLINE | ID: mdl-23640487

Subject(s)

Angiopoietins/blood; Angiopoietins/metabolism; Aortic Diseases/prevention & control; Atherosclerosis/prevention & control; Carotid Stenosis/prevention & control; Macrophages/metabolism; Angiopoietin-Like Protein 4; Angiopoietins/genetics; Animals; Aorta/metabolism; Aorta/pathology; Aortic Diseases/genetics; Aortic Diseases/metabolism; Aortic Diseases/pathology; Apolipoprotein E3/genetics; Atherosclerosis/genetics; Atherosclerosis/metabolism; Atherosclerosis/pathology; Carotid Arteries/pathology; Carotid Stenosis/blood; Carotid Stenosis/pathology; Cell Line; Chemotaxis; Cholesterol/blood; Diet, High-Fat; Disease Models, Animal; Female; Foam Cells/metabolism; Humans; Ligands; Lipoproteins, LDL/metabolism; Macrophage Activation; Macrophages/drug effects; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Time Factors; Toll-Like Receptor 3/agonists; Toll-Like Receptor 3/metabolism; Toll-Like Receptor 4/agonists; Toll-Like Receptor 4/metabolism; Triglycerides/blood; Up-Regulation

Key words

atherosclerosis; inflammation; lipoprotein lipase; lipoproteins; macrophages

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Full text: 1 Database: MEDLINE Main subject: Aortic Diseases / Carotid Stenosis / Angiopoietins / Atherosclerosis / Macrophages Type of study: Prognostic_studies Language: En Journal: Arterioscler Thromb Vasc Biol Journal subject: ANGIOLOGIA Year: 2013 Type: Article Affiliation country: Netherlands

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