TRIM13 (RFP2) downregulation decreases tumour cell growth in multiple myeloma through inhibition of NF Kappa B pathway and proteasome activity.

Gatt, Moshe E; Takada, Kohichi; Mani, Mala; Lerner, Mikael; Pick, Marjorie; Hideshima, Teru; Carrasco, Daniel E; Protopopov, Alexei; Ivanova, Elena; Sangfelt, Olle; Grandér, Dan; Barlogie, Bart; Shaughnessy, John D; Anderson, Kenneth C; Carrasco, Daniel R

Gatt, Moshe E; Takada, Kohichi; Mani, Mala; Lerner, Mikael; Pick, Marjorie; Hideshima, Teru; Carrasco, Daniel E; Protopopov, Alexei; Ivanova, Elena; Sangfelt, Olle; Grandér, Dan; Barlogie, Bart; Shaughnessy, John D; Anderson, Kenneth C; Carrasco, Daniel R.

Affiliation

Gatt ME; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

Br J Haematol ; 162(2): 210-20, 2013 Jul.

Article in En | MEDLINE | ID: mdl-23647456

Subject(s)

DNA-Binding Proteins/biosynthesis; Multiple Myeloma/genetics; Multiple Myeloma/pathology; NF-kappa B/antagonists & inhibitors; Proteasome Endopeptidase Complex/metabolism; Tumor Suppressor Proteins/biosynthesis; Apoptosis/genetics; Cell Cycle/genetics; Cell Division/genetics; Cell Line, Tumor; Cell Survival/genetics; Chromosome Deletion; Chromosomes, Human, Pair 13; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Down-Regulation; Gene Expression Profiling; Gene Knockdown Techniques; Humans; Multiple Myeloma/metabolism; NF-kappa B/genetics; NF-kappa B/metabolism; Proteasome Endopeptidase Complex/genetics; Tumor Suppressor Proteins/genetics; Tumor Suppressor Proteins/metabolism

Key words

13q; TRIM13 (RFP2); myeloma; proliferation; proteasome

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: NF-kappa B / Tumor Suppressor Proteins / Proteasome Endopeptidase Complex / DNA-Binding Proteins / Multiple Myeloma Limits: Humans Language: En Journal: Br J Haematol Year: 2013 Type: Article Affiliation country: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google