Identification of DNMT1 selective antagonists using a novel scintillation proximity assay.

Kilgore, Jessica A; Du, Xinlin; Melito, Lisa; Wei, Shuguang; Wang, Changguang; Chin, Hang Gyeong; Posner, Bruce; Pradhan, Sriharsa; Ready, Joseph M; Williams, Noelle S

Kilgore, Jessica A; Du, Xinlin; Melito, Lisa; Wei, Shuguang; Wang, Changguang; Chin, Hang Gyeong; Posner, Bruce; Pradhan, Sriharsa; Ready, Joseph M; Williams, Noelle S.

Affiliation

Kilgore JA; Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.

J Biol Chem ; 288(27): 19673-84, 2013 Jul 05.

Article in En | MEDLINE | ID: mdl-23671287

Subject(s)

Biological Assay; DNA (Cytosine-5-)-Methyltransferases/antagonists & inhibitors; Enzyme Inhibitors/pharmacology; Animals; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases/genetics; DNA (Cytosine-5-)-Methyltransferases/metabolism; DNA Methyltransferase 3A; Enzyme Inhibitors/chemistry; HeLa Cells; Humans; Hydrogen Peroxide/pharmacology; Mice; Oxidants/pharmacology; Sf9 Cells; Spodoptera; Tumor Suppressor Proteins/biosynthesis; Tumor Suppressor Proteins/genetics; DNA Methyltransferase 3B

Key words

DNA Methylation; DNA Methyltransferase; Gene Regulation; High Throughput Screening (HTS); Reactive Oxygen Species (ROS); Scintillation Proximity Assay

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Full text: 1 Database: MEDLINE Main subject: Biological Assay / DNA (Cytosine-5-)-Methyltransferases / Enzyme Inhibitors Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2013 Type: Article Affiliation country: United States

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