The antipsychotic agent chlorpromazine induces autophagic cell death by inhibiting the Akt/mTOR pathway in human U-87MG glioma cells.

Shin, Soon Young; Lee, Kyoung Sun; Choi, Yang-Kyu; Lim, Hyunjung Jade; Lee, Hong Ghi; Lim, Yoongho; Lee, Young Han

Shin, Soon Young; Lee, Kyoung Sun; Choi, Yang-Kyu; Lim, Hyunjung Jade; Lee, Hong Ghi; Lim, Yoongho; Lee, Young Han.

Affiliation

Shin SY; Department of Biological Sciences, College of Biological Science and Biotechnology, Research Center for Transcription Control, Konkuk University, Seoul 143-701, Republic of Korea.

Carcinogenesis ; 34(9): 2080-9, 2013 Sep.

Article in En | MEDLINE | ID: mdl-23689352

Subject(s)

Autophagy/drug effects; Chlorpromazine/administration & dosage; Glioma/drug therapy; Proto-Oncogene Proteins c-akt/genetics; TOR Serine-Threonine Kinases/genetics; Animals; Apoptosis Regulatory Proteins/metabolism; Beclin-1; Cell Line, Tumor; Cell Proliferation/drug effects; Gene Expression Regulation, Neoplastic; Glioma/pathology; Humans; Membrane Proteins/metabolism; Mice; PTEN Phosphohydrolase/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Proto-Oncogene Proteins c-akt/metabolism; TOR Serine-Threonine Kinases/metabolism; Xenograft Model Antitumor Assays

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Full text: 1 Database: MEDLINE Main subject: Autophagy / Chlorpromazine / Proto-Oncogene Proteins c-akt / TOR Serine-Threonine Kinases / Glioma Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Carcinogenesis Year: 2013 Type: Article

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