Runx1 is essential at two stages of early murine B-cell development.

Niebuhr, Birte; Kriebitzsch, Neele; Fischer, Meike; Behrens, Kira; Günther, Thomas; Alawi, Malik; Bergholz, Ulla; Müller, Ursula; Roscher, Susanne; Ziegler, Marion; Buchholz, Frank; Grundhoff, Adam; Stocking, Carol

Niebuhr, Birte; Kriebitzsch, Neele; Fischer, Meike; Behrens, Kira; Günther, Thomas; Alawi, Malik; Bergholz, Ulla; Müller, Ursula; Roscher, Susanne; Ziegler, Marion; Buchholz, Frank; Grundhoff, Adam; Stocking, Carol.

Affiliation

Niebuhr B; Molecular Pathology, Heinrich-Pette-Institute, Leibniz Institute for Experimental Virology, Martinistrasse 52, Hamburg, Germany.

Blood ; 122(3): 413-23, 2013 Jul 18.

Article in En | MEDLINE | ID: mdl-23704093

Subject(s)

B-Lymphocytes/cytology; B-Lymphocytes/immunology; Core Binding Factor Alpha 2 Subunit/metabolism; Animals; Apoptosis/genetics; Binding Sites; Cell Differentiation/immunology; Cell Lineage/genetics; Cell Lineage/immunology; Cell Proliferation; Cell Survival/genetics; Cell Survival/immunology; Chromosomes, Human, Pair 12/genetics; Chromosomes, Human, Pair 21/genetics; Core Binding Factor Alpha 2 Subunit/deficiency; Enhancer Elements, Genetic/genetics; Gene Deletion; Gene Expression Regulation, Developmental; Gene Expression Regulation, Leukemic; Gene Targeting; Genome/genetics; Humans; Ikaros Transcription Factor; Mice; Mice, Inbred C57BL; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics; Protein Binding/genetics; Proto-Oncogene Proteins c-bcl-2/metabolism; Trans-Activators/genetics; Trans-Activators/metabolism; Translocation, Genetic

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Full text: 1 Database: MEDLINE Main subject: B-Lymphocytes / Core Binding Factor Alpha 2 Subunit Limits: Animals / Humans Language: En Journal: Blood Year: 2013 Type: Article Affiliation country: Germany

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