RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms.

Fritsch, Ralph; de Krijger, Inge; Fritsch, Kornelia; George, Roger; Reason, Beth; Kumar, Madhu S; Diefenbacher, Markus; Stamp, Gordon; Downward, Julian

Fritsch, Ralph; de Krijger, Inge; Fritsch, Kornelia; George, Roger; Reason, Beth; Kumar, Madhu S; Diefenbacher, Markus; Stamp, Gordon; Downward, Julian.

Affiliation

Fritsch R; Signal Transduction Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.

Cell ; 153(5): 1050-63, 2013 May 23.

Article in En | MEDLINE | ID: mdl-23706742

Subject(s)

Class I Phosphatidylinositol 3-Kinases/metabolism; Fibroblasts/metabolism; Signal Transduction; ras Proteins/metabolism; Animals; Chemotaxis; Class I Phosphatidylinositol 3-Kinases/chemistry; Fibrosis/chemically induced; Fibrosis/prevention & control; GTP-Binding Protein Regulators/metabolism; Guanine Nucleotide Exchange Factors/metabolism; Isoenzymes/metabolism; Lung/pathology; Mice; Protein Interaction Domains and Motifs; rac1 GTP-Binding Protein/metabolism; ras Proteins/chemistry

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Full text: 1 Database: MEDLINE Main subject: Signal Transduction / Ras Proteins / Class I Phosphatidylinositol 3-Kinases / Fibroblasts Limits: Animals Language: En Journal: Cell Year: 2013 Type: Article Affiliation country: United kingdom

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