Enhancement of CD154/IL4 proliferation by the T follicular helper (Tfh) cytokine, IL21 and increased numbers of circulating cells resembling Tfh cells in chronic lymphocytic leukaemia.

Ahearne, Matthew J; Willimott, Shaun; Piñon, Lucia; Kennedy, D Benjamin; Miall, Fiona; Dyer, Martin J S; Wagner, Simon D

Ahearne, Matthew J; Willimott, Shaun; Piñon, Lucia; Kennedy, D Benjamin; Miall, Fiona; Dyer, Martin J S; Wagner, Simon D.

Affiliation

Ahearne MJ; Department of Cancer Studies and Molecular Medicine, MRC Toxicology Unit, University of Leicester, Leicester, UK.

Br J Haematol ; 162(3): 360-70, 2013 Aug.

Article in En | MEDLINE | ID: mdl-23710828

Subject(s)

Cytokines/immunology; Leukemia, Lymphocytic, Chronic, B-Cell/immunology; T-Lymphocyte Subsets/immunology; T-Lymphocytes, Helper-Inducer/immunology; Apoptosis/immunology; CD40 Ligand/immunology; Cell Differentiation/immunology; Cell Proliferation; Female; Humans; Interleukin-4/immunology; Interleukins/immunology; Interleukins/metabolism; Leukemia, Lymphocytic, Chronic, B-Cell/pathology; Lymph Nodes/immunology; Lymphocyte Count; Male; Programmed Cell Death 1 Receptor/metabolism; Tumor Cells, Cultured; Tumor Microenvironment/immunology

Key words

CD154; IL21; T follicular helper; chronic lymphocytic leukaemia; microenvironment

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Full text: 1 Database: MEDLINE Main subject: Leukemia, Lymphocytic, Chronic, B-Cell / Cytokines / T-Lymphocyte Subsets / T-Lymphocytes, Helper-Inducer Limits: Female / Humans / Male Language: En Journal: Br J Haematol Year: 2013 Type: Article Affiliation country: United kingdom

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