Card9 mediates intestinal epithelial cell restitution, T-helper 17 responses, and control of bacterial infection in mice.

Sokol, Harry; Conway, Kara L; Zhang, Mei; Choi, Myunghwan; Morin, Bret; Cao, Zhifang; Villablanca, Eduardo J; Li, Chun; Wijmenga, Cisca; Yun, Seok Hyun; Shi, Hai Ning; Xavier, Ramnik J

Sokol, Harry; Conway, Kara L; Zhang, Mei; Choi, Myunghwan; Morin, Bret; Cao, Zhifang; Villablanca, Eduardo J; Li, Chun; Wijmenga, Cisca; Yun, Seok Hyun; Shi, Hai Ning; Xavier, Ramnik J.

Affiliation

Sokol H; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Gastroenterology ; 145(3): 591-601.e3, 2013 Sep.

Article in En | MEDLINE | ID: mdl-23732773

Subject(s)

Adaptor Proteins, Signal Transducing/metabolism; Citrobacter rodentium; Colitis/metabolism; Enterobacteriaceae Infections/metabolism; Intestinal Mucosa/metabolism; Th17 Cells/metabolism; Animals; Biomarkers/metabolism; CARD Signaling Adaptor Proteins; Colitis/etiology; Colitis/immunology; Colitis/pathology; Cytokines/metabolism; Dextran Sulfate; Enterobacteriaceae Infections/immunology; Enterobacteriaceae Infections/pathology; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Immunity, Innate; Intestinal Mucosa/immunology; Intestinal Mucosa/microbiology; Intestinal Mucosa/pathology; Male; Mice; Mice, Inbred C57BL; Reverse Transcriptase Polymerase Chain Reaction

Key words

AMP; ASCA; CARD9; CFU; Ccl20; Colitis; DSS; IFN; IL; ILC; Inflammatory Response; JNK; LP; MLN; Mouse Model; PBS; SFB; T-helper; TNF; Th; antimicrobial peptide; antiSaccharomyces cerevisiae antibody; c-Jun-N-terminal kinase; caspase recruitment domain 9; chemokine (C-C motif) ligand 20; colony forming unit; dextran sulfate sodium; innate lymphoid cell; interferon; interleukin; lamina propria; mesenteric lymph node; phosphate-buffered saline; qRT-PCR; quantitative reverse-transcription polymerase chain reaction; segmented filamentous bacteria; tumor necrosis factor

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Full text: 1 Database: MEDLINE Main subject: Colitis / Citrobacter rodentium / Adaptor Proteins, Signal Transducing / Enterobacteriaceae Infections / Th17 Cells / Intestinal Mucosa Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: Gastroenterology Year: 2013 Type: Article Affiliation country: United States

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