Topical cyclosporine in the treatment of allergic conjunctivitis: a meta-analysis.
Ophthalmology
; 120(11): 2197-203, 2013 Nov.
Article
in En
| MEDLINE
| ID: mdl-23743438
ABSTRACT
PURPOSE:
To assess the efficacy and safety of topical cyclosporine versus placebo in the treatment of allergic conjunctivitis.DESIGN:
Systematic review and meta-analysis.PARTICIPANTS:
Seven qualified studies incorporating 306 eyes of 153 patients were analyzed.METHODS:
Searches of randomized controlled trials were conducted in MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, and the World Health Organization International Clinical Trials Registry Platform. MAIN OUTCOMEMEASURES:
We assessed the methodologic quality of individual included trials and performed meta-analyses using the random effects model if P<0.1 in the test for heterogeneity, or otherwise used the fixed effects model. We assessed scores of composite signs and symptoms, reduction in steroid eye drop use in steroid-dependent patients, and safety outcomes (i.e., stinging or burning sensation).RESULTS:
At 2 weeks of follow-up or longer, evidence suggests a statistically significant improvement in the composite signs (standardized mean difference [SMD], -1.21; 95% confidence interval [CI], -1.80 to -0.62; I(2) = 71%) and symptoms (SMD, -0.84; 95% CI, -1.51 to -0.16; I(2) = 80%) after topical cyclosporine treatment for allergic conjunctivitis regardless of the dosage of treatment. There was a significant reduction (mean difference, -61.16; 95% CI, -101.61 to -20.72; I(2) = 58%) in the use of steroid eye drops in patients with steroid-dependent allergic conjunctivitis. Stinging or burning sensation (odds ratio, 2.56; 95% CI, 0.19-35.06; I(2) = 73%) was common in both the cyclosporine and placebo groups.CONCLUSIONS:
This systematic review and meta-analysis suggests topical cyclosporine could be an effective and safe treatment method for allergic conjunctivitis. Further randomized controlled trials with larger sample sizes and standardized outcome measurements, follow-up periods, and cyclosporine concentrations are warranted to determine the short- and long-term efficacy and safety and the minimal effective dosage of topical cyclosporine for allergic conjunctivitis.
Full text:
1
Database:
MEDLINE
Main subject:
Conjunctivitis, Allergic
/
Cyclosporine
/
Immunosuppressive Agents
Type of study:
Clinical_trials
/
Prognostic_studies
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Ophthalmology
Year:
2013
Type:
Article
Affiliation country:
China