Evaluation of initial and steady-state gatifloxacin pharmacokinetics and dose in pulmonary tuberculosis patients by using monte carlo simulations.

Smythe, Wynand; Merle, Corinne S; Rustomjee, Roxana; Gninafon, Martin; Lo, Mame Bocar; Bah-Sow, Oumou; Olliaro, Piero L; Lienhardt, Christian; Horton, John; Smith, Peter; McIlleron, Helen; Simonsson, Ulrika S H

Smythe, Wynand; Merle, Corinne S; Rustomjee, Roxana; Gninafon, Martin; Lo, Mame Bocar; Bah-Sow, Oumou; Olliaro, Piero L; Lienhardt, Christian; Horton, John; Smith, Peter; McIlleron, Helen; Simonsson, Ulrika S H.

Affiliation

Smythe W; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

Antimicrob Agents Chemother ; 57(9): 4164-71, 2013 Sep.

Article in En | MEDLINE | ID: mdl-23774436

Subject(s)

Antitubercular Agents/pharmacokinetics; Drug Dosage Calculations; Fluoroquinolones/pharmacokinetics; Tuberculosis, Pulmonary/drug therapy; Adult; Antitubercular Agents/therapeutic use; Area Under Curve; Coinfection; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Female; Fluoroquinolones/therapeutic use; Gatifloxacin; HIV Infections/virology; Humans; Isoniazid/therapeutic use; Male; Monte Carlo Method; Pyrazinamide/therapeutic use; Rifampin/therapeutic use; Tuberculosis, Pulmonary/microbiology

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Full text: 1 Database: MEDLINE Main subject: Tuberculosis, Pulmonary / Fluoroquinolones / Drug Dosage Calculations / Antitubercular Agents Type of study: Clinical_trials / Health_economic_evaluation / Prognostic_studies Limits: Adult / Female / Humans / Male Language: En Journal: Antimicrob Agents Chemother Year: 2013 Type: Article Affiliation country: South Africa

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