Risks of reproducing with a genetic disorder.
Semin Reprod Med
; 31(4): 258-66, 2013 Jul.
Article
in En
| MEDLINE
| ID: mdl-23775381
ABSTRACT
Male-factor infertility is the cause of reproductive issues in many couples. For approximately 15% of these men, the origin of the infertility is genetic. These causes include both chromosomal and single-gene disorders frequently impacting spermatogenesis. By identifying the genetic mechanism behind the infertility, we determine the ability of the couple to use assisted reproduction technologies. Use of these methods has ignited a new spectrum of concerns for the genetic competence of the offspring. By knowing what specific genetic risks exist for the offspring of men with these particular disorders, we are able to use preimplantation genetic diagnosis to detect these problems.
Full text:
1
Database:
MEDLINE
Main subject:
Genetic Diseases, Inborn
/
Infertility, Male
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Semin Reprod Med
Journal subject:
MEDICINA REPRODUTIVA
Year:
2013
Type:
Article
Affiliation country:
United States