Selective inhibition of human acetylcholinesterase by xanthine derivatives: in vitro inhibition and molecular modeling investigations.

Mohamed, Tarek; Osman, Wesseem; Tin, Gary; Rao, Praveen P N

Mohamed, Tarek; Osman, Wesseem; Tin, Gary; Rao, Praveen P N.

Affiliation

Mohamed T; School of Pharmacy, Health Sciences Campus, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1.

Bioorg Med Chem Lett ; 23(15): 4336-41, 2013 Aug 01.

Article in En | MEDLINE | ID: mdl-23791077

Subject(s)

Acetylcholinesterase/chemistry; Cholinesterase Inhibitors/chemistry; Xanthine/chemistry; Acetylcholinesterase/metabolism; Binding Sites; Butyrylcholinesterase/chemistry; Butyrylcholinesterase/metabolism; Caffeine/chemistry; Catalytic Domain; Cholinesterase Inhibitors/metabolism; Humans; Hydrogen Bonding; Molecular Docking Simulation; Pentoxifylline/chemistry; Pentoxifylline/metabolism; Protein Binding; Thermodynamics; Xanthine/metabolism; Xanthines/chemistry; Xanthines/metabolism

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Full text: 1 Database: MEDLINE Main subject: Acetylcholinesterase / Cholinesterase Inhibitors / Xanthine Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2013 Type: Article

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