Left ventricular volumes and systolic function after long-term right ventricular pacing may be predicted by paced QRS duration, but not pacing site.
Heart Lung Circ
; 23(1): 43-8, 2014 Jan.
Article
in En
| MEDLINE
| ID: mdl-23806197
ABSTRACT
BACKGROUND:
Long-term right ventricular apical (RVA) pacing causes adverse left ventricular (LV) remodelling and clinical outcomes.METHODS:
Forty-one patients (19 men, mean age 70.9±14.2, 23 right ventricular septal and 18 RVA pacing) underwent pacemaker implantation for atrioventricular block. LV volumes and left ventricular ejection fraction (LVEF) were assessed by echocardiography 39.3±17.2 months after implantation. Predictors of left ventricular systolic volume (LVESV), left ventricular diastolic volume (LVEDV) and LVEF were analysed.RESULTS:
No difference was found between RVA pacing and right ventricular septal pacing groups in LVESV (40.6±22.6 vs 33±14.4ml; p=0.199), LVEDV (88.2±31.2 vs 73.7±23.9ml; p=0.102) and LVEF (56.1±8.6 vs 56±6.6%; p=0.996). With multivariate stepwise regression, only pQRSd and renal impairment independently predicted LVESV (ß=0.522, 95% CI 0.242-0.802; p=0.001 and ß=40.3, 95% CI 17.6-62.9; p=0.001 respectively), LVEDV (ß=0.786, 95% CI 0.338-1.235; p=0.001 and ß=42.8, 95% CI 6.6-79; p=0.022 respectively) and LVEF (ß=-0.161, 95% CI -0.283 to -0.04; p=0.011 and ß=-14.8, 95% CI -24.6 to -5.0; p=0.004 respectively).CONCLUSIONS:
pQRSd and renal impairment, but not pacing site or baseline LVEF, may be predictors for LV volumes and systolic function after long-term RV pacing. pQRSd may be target for pacing site optimisation.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Pacemaker, Artificial
/
Stroke Volume
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Cardiac Pacing, Artificial
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Ventricular Function, Left
/
Ventricular Remodeling
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Heart Lung Circ
Journal subject:
ANGIOLOGIA
/
CARDIOLOGIA
Year:
2014
Type:
Article