Intercellular Signaling Peptides and Proteins/metabolism; NAV1.7 Voltage-Gated Sodium Channel/metabolism; Nerve Tissue Proteins/metabolism; Sensory Receptor Cells/metabolism; Sumoylation/physiology; Amino Acid Substitution; Animals; Catecholamines/pharmacology; Cell Differentiation/drug effects; Cell Differentiation/physiology; Cysteine Endopeptidases/genetics; Cysteine Endopeptidases/metabolism; Endopeptidases/genetics; Endopeptidases/metabolism; HEK293 Cells; Humans; Intercellular Signaling Peptides and Proteins/genetics; Multienzyme Complexes/genetics; Multienzyme Complexes/metabolism; Mutation, Missense; NAV1.1 Voltage-Gated Sodium Channel/genetics; NAV1.1 Voltage-Gated Sodium Channel/metabolism; NAV1.3 Voltage-Gated Sodium Channel/genetics; NAV1.3 Voltage-Gated Sodium Channel/metabolism; NAV1.7 Voltage-Gated Sodium Channel/genetics; Nerve Tissue Proteins/genetics; Protein Transport/drug effects; Protein Transport/physiology; SUMO-1 Protein/genetics; SUMO-1 Protein/metabolism; Sensory Receptor Cells/cytology; Sodium Channels/genetics; Sodium Channels/metabolism; Sumoylation/drug effects; Ubiquitin-Conjugating Enzymes/genetics; Ubiquitin-Conjugating Enzymes/metabolism

CRMP2; NaV1.1; NaV1.7; Patch Clamp Electrophysiology; Post-translational Modification; Signaling; Sodium Channels; Sumoylation; Trafficking