Pharmacological correction of long QT-linked mutations in KCNH2 (hERG) increases the trafficking of Kv11.1 channels stored in the transitional endoplasmic reticulum.

Smith, Jennifer L; Reloj, Allison R; Nataraj, Parvathi S; Bartos, Daniel C; Schroder, Elizabeth A; Moss, Arthur J; Ohno, Seiko; Horie, Minoru; Anderson, Corey L; January, Craig T; Delisle, Brian P

Smith, Jennifer L; Reloj, Allison R; Nataraj, Parvathi S; Bartos, Daniel C; Schroder, Elizabeth A; Moss, Arthur J; Ohno, Seiko; Horie, Minoru; Anderson, Corey L; January, Craig T; Delisle, Brian P.

Affiliation

Smith JL; Center for Muscle Biology, Department of Physiology, University of Kentucky, Lexington, Kentucky;

Am J Physiol Cell Physiol ; 305(9): C919-30, 2013 Nov 01.

Article in En | MEDLINE | ID: mdl-23864605

Subject(s)

Endoplasmic Reticulum/genetics; Ether-A-Go-Go Potassium Channels/genetics; Long QT Syndrome/genetics; Mutation, Missense/genetics; Adolescent; Adult; Aged; Anti-Arrhythmia Agents/pharmacology; ERG1 Potassium Channel; Endoplasmic Reticulum/drug effects; Endoplasmic Reticulum/metabolism; Ether-A-Go-Go Potassium Channels/metabolism; Female; HEK293 Cells; Humans; Long QT Syndrome/metabolism; Male; Middle Aged; Piperidines/pharmacology; Potassium Channel Blockers/pharmacology; Protein Transport/drug effects; Protein Transport/physiology; Pyridines/pharmacology; Young Adult

Key words

long QT syndrome; potassium channel; trafficking

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Full text: 1 Database: MEDLINE Main subject: Long QT Syndrome / Mutation, Missense / Endoplasmic Reticulum / Ether-A-Go-Go Potassium Channels Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Am J Physiol Cell Physiol Journal subject: FISIOLOGIA Year: 2013 Type: Article

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