Pan-FGFR inhibition leads to blockade of FGF23 signaling, soft tissue mineralization, and cardiovascular dysfunction.

Yanochko, Gina M; Vitsky, Allison; Heyen, Jonathan R; Hirakawa, Brad; Lam, Justine L; May, Jeff; Nichols, Tim; Sace, Frederick; Trajkovic, Dusko; Blasi, Eileen

Yanochko, Gina M; Vitsky, Allison; Heyen, Jonathan R; Hirakawa, Brad; Lam, Justine L; May, Jeff; Nichols, Tim; Sace, Frederick; Trajkovic, Dusko; Blasi, Eileen.

Affiliation

Yanochko GM; * Drug Safety Research & Development, and.

Toxicol Sci ; 135(2): 451-64, 2013 Oct.

Article in En | MEDLINE | ID: mdl-23872713

Subject(s)

Cardiovascular System/physiopathology; Fibroblast Growth Factors/metabolism; Receptors, Fibroblast Growth Factor/antagonists & inhibitors; Signal Transduction; Animals; Base Sequence; Cardiovascular System/metabolism; Cell Line; DNA Primers; Fibroblast Growth Factor-23; Humans; Phosphorylation; Rats; Rats, Wistar

Key words

fibroblast growth factor receptor; fibroblast growth factor-23; klotho; mineralization; phosphate; vitamin D.

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Full text: 1 Database: MEDLINE Main subject: Cardiovascular System / Signal Transduction / Receptors, Fibroblast Growth Factor / Fibroblast Growth Factors Limits: Animals / Humans Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2013 Type: Article

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