Antibody conjugated PLGA nanoparticles for targeted delivery of paclitaxel palmitate: efficacy and biofate in a lung cancer mouse model.

Karra, Nour; Nassar, Taher; Ripin, Alina Nemirovski; Schwob, Ouri; Borlak, Jürgen; Benita, Simon

Karra, Nour; Nassar, Taher; Ripin, Alina Nemirovski; Schwob, Ouri; Borlak, Jürgen; Benita, Simon.

Affiliation

Karra N; The Institute for Drug Research, The School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, POB 12065, Jerusalem, 91120, Israel.

Small ; 9(24): 4221-36, 2013 Dec 20.

Article in En | MEDLINE | ID: mdl-23873835

Subject(s)

Antibodies/chemistry; Lactic Acid/chemistry; Lung Neoplasms/drug therapy; Nanoparticles/administration & dosage; Paclitaxel/chemistry; Palmitates/administration & dosage; Polyglycolic Acid/chemistry; Amides/chemistry; Animals; Antibodies, Monoclonal, Humanized/administration & dosage; Antibodies, Monoclonal, Humanized/chemistry; Area Under Curve; Cell Line, Tumor; Cetuximab; Cysteine/chemistry; Drug Delivery Systems; ErbB Receptors/chemistry; Humans; Immunotherapy; Mice; Mice, SCID; Nanoparticles/chemistry; Nanotechnology; Neoplasm Transplantation; Polylactic Acid-Polyglycolic Acid Copolymer; Sulfhydryl Compounds/chemistry; Surface Plasmon Resonance; Surface Properties

Key words

PLGA nanoparticles; biodistribution; conjugation; oleyl cysteineamide; paclitaxel-palmitate

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Full text: 1 Database: MEDLINE Main subject: Palmitates / Polyglycolic Acid / Paclitaxel / Lactic Acid / Nanoparticles / Lung Neoplasms / Antibodies Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Small Journal subject: ENGENHARIA BIOMEDICA Year: 2013 Type: Article Affiliation country: Israel

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