Spatially distinct roles of class Ia PI3K isoforms in the development and maintenance of PTEN hamartoma tumor syndrome.

Wang, Qi; Von, Thanh; Bronson, Roderick; Ruan, Minzi; Mu, Wenxia; Huang, Alan; Maira, Sauveur-Michel; Zhao, Jean J

Wang, Qi; Von, Thanh; Bronson, Roderick; Ruan, Minzi; Mu, Wenxia; Huang, Alan; Maira, Sauveur-Michel; Zhao, Jean J.

Affiliation

Wang Q; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

Genes Dev ; 27(14): 1568-80, 2013 Jul 15.

Article in En | MEDLINE | ID: mdl-23873941

Subject(s)

Class I Phosphatidylinositol 3-Kinases/genetics; Class I Phosphatidylinositol 3-Kinases/metabolism; Hamartoma Syndrome, Multiple/pathology; Animals; Cell Survival/drug effects; Cells, Cultured; Epidermis/drug effects; Epidermis/enzymology; Epidermis/pathology; Hamartoma Syndrome, Multiple/genetics; Mice; Oncogene Protein v-akt/metabolism; PTEN Phosphohydrolase/genetics; Phosphorylation; Protein Isoforms; Protein Kinase Inhibitors/pharmacology

Key words

PI3K inhibitors; PI3K isoforms; PTEN hamartoma tumor syndrome; genetic mouse models; skin

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Full text: 1 Database: MEDLINE Main subject: Hamartoma Syndrome, Multiple / Class I Phosphatidylinositol 3-Kinases Limits: Animals Language: En Journal: Genes Dev Journal subject: BIOLOGIA MOLECULAR Year: 2013 Type: Article Affiliation country: United States

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