Low molecular weight heparin relieves experimental colitis in mice by downregulating IL-1ß and inhibiting syndecan-1 shedding in the intestinal mucosa.

Wang, Xian-fei; Li, Ai-ming; Li, Jing; Lin, Shi-yong; Chen, Chu-di; Zhou, You-Lian; Wang, Xia; Chen, Cun-long; Liu, Si-de; Chen, Ye

Wang, Xian-fei; Li, Ai-ming; Li, Jing; Lin, Shi-yong; Chen, Chu-di; Zhou, You-Lian; Wang, Xia; Chen, Cun-long; Liu, Si-de; Chen, Ye.

Affiliation

Wang XF; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

PLoS One ; 8(7): e66397, 2013.

Article in En | MEDLINE | ID: mdl-23874391

Subject(s)

Colitis/drug therapy; Down-Regulation/drug effects; Heparin, Low-Molecular-Weight/pharmacology; Interleukin-1beta/metabolism; Intestinal Mucosa/metabolism; Syndecan-1/blood; Analysis of Variance; Animals; Colitis/etiology; DNA Primers/genetics; Dextran Sulfate/toxicity; Heparin, Low-Molecular-Weight/metabolism; Immunoblotting; Immunohistochemistry; Interleukin-10/metabolism; Male; Mice; Mice, Inbred C57BL; Reverse Transcriptase Polymerase Chain Reaction

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Full text: 1 Database: MEDLINE Main subject: Down-Regulation / Colitis / Heparin, Low-Molecular-Weight / Interleukin-1beta / Syndecan-1 / Intestinal Mucosa Type of study: Etiology_studies Limits: Animals Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2013 Type: Article Affiliation country: China

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