Gamma-secretase inhibition attenuates oxaliplatin-induced apoptosis through increased Mcl-1 and/or Bcl-xL in human colon cancer cells.

Timme, Cindy R; Gruidl, Mike; Yeatman, Timothy J

Timme, Cindy R; Gruidl, Mike; Yeatman, Timothy J.

Affiliation

Timme CR; Department of Experimental Therapeutics, Moffitt Cancer Center, Tampa, FL, USA.

Apoptosis ; 18(10): 1163-74, 2013 Oct.

Article in En | MEDLINE | ID: mdl-23887890

Subject(s)

Adenocarcinoma/pathology; Amyloid Precursor Protein Secretases/antagonists & inhibitors; Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Colonic Neoplasms/pathology; Cyclic S-Oxides/pharmacology; Myeloid Cell Leukemia Sequence 1 Protein/metabolism; Organoplatinum Compounds/pharmacology; Thiadiazoles/pharmacology; bcl-X Protein/metabolism; Adenocarcinoma/enzymology; Cell Line, Tumor; Colonic Neoplasms/enzymology; Drug Synergism; Humans; Indoles; Myeloid Cell Leukemia Sequence 1 Protein/antagonists & inhibitors; Myeloid Cell Leukemia Sequence 1 Protein/genetics; Oxaliplatin; Pyrroles/pharmacology; RNA, Small Interfering/genetics; Signal Transduction/drug effects; bcl-X Protein/antagonists & inhibitors; bcl-X Protein/genetics

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Full text: 1 Database: MEDLINE Main subject: Organoplatinum Compounds / Thiadiazoles / Adenocarcinoma / Apoptosis / Colonic Neoplasms / Cyclic S-Oxides / Bcl-X Protein / Amyloid Precursor Protein Secretases / Myeloid Cell Leukemia Sequence 1 Protein / Antineoplastic Agents Limits: Humans Language: En Journal: Apoptosis Year: 2013 Type: Article Affiliation country: United States

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