Overexpression of E2F3 promotes proliferation of functional human ß cells without induction of apoptosis.

Rady, Brian; Chen, Yanmei; Vaca, Pilar; Wang, Qian; Wang, Yong; Salmon, Patrick; Oberholzer, José

Rady, Brian; Chen, Yanmei; Vaca, Pilar; Wang, Qian; Wang, Yong; Salmon, Patrick; Oberholzer, José.

Affiliation

Rady B; Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA.

Cell Cycle ; 12(16): 2691-702, 2013 Aug 15.

Article in En | MEDLINE | ID: mdl-23907129

Subject(s)

Cell Proliferation; E2F3 Transcription Factor/metabolism; Insulin-Secreting Cells/physiology; Analysis of Variance; Animals; Humans; Immunoblotting; Insulin-Secreting Cells/metabolism; Mice; Microfluidic Analytical Techniques; Microscopy, Fluorescence; Rats; Reverse Transcriptase Polymerase Chain Reaction

Key words

E2F; E2F3; beta-cell proliferation; beta-cell replication; cell cycle; insulin-secreting cells; insulinoma; islet transplant; type I diabetes

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Full text: 1 Database: MEDLINE Main subject: Cell Proliferation / Insulin-Secreting Cells / E2F3 Transcription Factor Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cell Cycle Year: 2013 Type: Article Affiliation country: United States

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