Diastereoselective radical addition to γ-alkyl-α-methylene-γ-butyrolactams and the synthesis of a chiral pyroglutamic acid derivative.
Beilstein J Org Chem
; 9: 1432-6, 2013.
Article
in En
| MEDLINE
| ID: mdl-23946839
ABSTRACT
The cis- and trans-stereoselective radical additions to α-methylene-γ-alkyl- γ-lactams were investigated and the scope and limitation of the reaction were also revealed. This stereoselective radical reaction was used for synthesis of chiral pyroglutamic acid derivatives starting from a commercially available chiral amino acid.
Full text:
1
Database:
MEDLINE
Language:
En
Journal:
Beilstein J Org Chem
Year:
2013
Type:
Article
Affiliation country:
Japan