Association between increased epicardial adipose tissue volume and coronary plaque composition.
Heart Vessels
; 29(5): 569-77, 2014 Sep.
Article
in En
| MEDLINE
| ID: mdl-23982316
ABSTRACT
To assess the relationship between epicardial adipose tissue volume (EATV) and plaque vulnerability in significant coronary stenosis using a 40-MHz intravascular ultrasound (IVUS) imaging system (iMap-IVUS), we analyzed 130 consecutive patients with coronary stenosis who underwent dual-source computed tomography (CT) and cardiac catheterization. Culprit lesions were imaged by iMap-IVUS before stenting. The iMAP-IVUS system classified coronary plaque components as fibrous, lipid, necrotic, or calcified tissue, based on the radiofrequency spectrum. Epicardial adipose tissue was measured as the tissue ranging from -190 to -30 Hounsfield units. EATV, calculated as the sum of the fat areas on short-axis images, was 85.0 ± 34.0 cm(3). There was a positive correlation between EATV and the percentage of necrotic plaque tissue (R (2) = 0.34, P < 0.01), while there was a negative correlation between EATV and the percentage of fibrous tissue (R (2) = 0.24, P < 0.01). Multivariate analysis revealed that an increased low-density lipoprotein cholesterol level (ß = 0.15, P = 0.03) and EATV (ß = 0.14, P = 0.02) were independently associated with the percentage of necrotic plaque tissue. An increase in EATV was associated with the development of coronary atherosclerosis and, potentially, with the most dangerous type of plaque.
Full text:
1
Database:
MEDLINE
Main subject:
Pericardium
/
Coronary Artery Disease
/
Adipose Tissue
/
Ultrasonography, Interventional
/
Coronary Vessels
/
Coronary Stenosis
/
Plaque, Atherosclerotic
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Heart Vessels
Journal subject:
CARDIOLOGIA
Year:
2014
Type:
Article