A model of sensitivity and resistance to histone deacetylase inhibitors in diffuse large B cell lymphoma: Role of cyclin-dependent kinase inhibitors.

Tula-Sanchez, Ana A; Havas, Aaron P; Alonge, Peter J; Klein, Mary E; Doctor, Samantha R; Pinkston, William; Glinsmann-Gibson, Betty J; Rimsza, Lisa M; Smith, Catharine L

Tula-Sanchez, Ana A; Havas, Aaron P; Alonge, Peter J; Klein, Mary E; Doctor, Samantha R; Pinkston, William; Glinsmann-Gibson, Betty J; Rimsza, Lisa M; Smith, Catharine L.

Affiliation

Tula-Sanchez AA; Department of Pharmacology and Toxicology; College of Pharmacy; University of Arizona; Tucson, AZ USA.

Cancer Biol Ther ; 14(10): 949-61, 2013 Oct 01.

Article in En | MEDLINE | ID: mdl-23982416

Subject(s)

Antineoplastic Agents/pharmacology; Cyclin-Dependent Kinase Inhibitor p21/physiology; Cyclin-Dependent Kinase Inhibitor p27/physiology; Histone Deacetylase Inhibitors/pharmacology; Hydroxamic Acids/pharmacology; Lymphoma, Large B-Cell, Diffuse/drug therapy; Sulfonamides/pharmacology; Apoptosis; Cell Line, Tumor/drug effects; Cell Proliferation/drug effects; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic/drug effects; Humans; Inhibitory Concentration 50; Lymphoma, Large B-Cell, Diffuse/metabolism; Phosphorylation; Protein Processing, Post-Translational/drug effects; Proto-Oncogene Proteins c-bcl-2/metabolism; Proto-Oncogene Proteins c-myc/metabolism; Retinoblastoma Protein/metabolism; Up-Regulation/drug effects

Key words

BCL2; MYC; cell cycle; cell cycle inhibitors; drug resistance; histone deacetylase inhibitor; lymphoma

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Full text: 1 Database: MEDLINE Main subject: Sulfonamides / Lymphoma, Large B-Cell, Diffuse / Cyclin-Dependent Kinase Inhibitor p21 / Cyclin-Dependent Kinase Inhibitor p27 / Histone Deacetylase Inhibitors / Hydroxamic Acids / Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Cancer Biol Ther Journal subject: NEOPLASIAS / TERAPEUTICA Year: 2013 Type: Article

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