UBE2QL1 is disrupted by a constitutional translocation associated with renal tumor predisposition and is a novel candidate renal tumor suppressor gene.

Wake, Naomi C; Ricketts, Christopher J; Morris, Mark R; Prigmore, Elena; Gribble, Susan M; Skytte, Anne-Bine; Brown, Michael; Clarke, Noel; Banks, Rosamonde E; Hodgson, Shirley; Turnell, Andrew S; Maher, Eamonn R; Woodward, Emma R

Wake, Naomi C; Ricketts, Christopher J; Morris, Mark R; Prigmore, Elena; Gribble, Susan M; Skytte, Anne-Bine; Brown, Michael; Clarke, Noel; Banks, Rosamonde E; Hodgson, Shirley; Turnell, Andrew S; Maher, Eamonn R; Woodward, Emma R.

Affiliation

Wake NC; Centre for Rare Diseases and Personalised Medicine, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

Hum Mutat ; 34(12): 1650-61, 2013 Dec.

Article in En | MEDLINE | ID: mdl-24000165

Subject(s)

Genes, Tumor Suppressor; Genetic Predisposition to Disease; Kidney Neoplasms/genetics; Translocation, Genetic; Ubiquitin-Conjugating Enzymes/genetics; Adult; Base Sequence; Cell Cycle Proteins/metabolism; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic/genetics; Chromosome Breakpoints; Chromosomes, Human, Pair 19; Chromosomes, Human, Pair 5; DNA Methylation; Epigenesis, Genetic; F-Box Proteins/metabolism; F-Box-WD Repeat-Containing Protein 7; Female; Gene Expression Regulation, Neoplastic; Humans; Kidney Neoplasms/metabolism; Molecular Sequence Data; Protein Binding; Protein Transport; Ubiquitin-Conjugating Enzymes/chemistry; Ubiquitin-Conjugating Enzymes/metabolism; Ubiquitin-Protein Ligases/metabolism

Key words

FBXW7; UBE2QL1; renal cell carcinoma; ubiquitin conjugating enzyme

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Full text: 1 Database: MEDLINE Main subject: Translocation, Genetic / Genes, Tumor Suppressor / Genetic Predisposition to Disease / Ubiquitin-Conjugating Enzymes / Kidney Neoplasms Type of study: Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans Language: En Journal: Hum Mutat Journal subject: GENETICA MEDICA Year: 2013 Type: Article Affiliation country: United kingdom

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