The development of selective inhibitors of NagZ: increased susceptibility of Gram-negative bacteria to ß-lactams.

Stubbs, Keith A; Bacik, John-Paul; Perley-Robertson, G Evan; Whitworth, Garrett E; Gloster, Tracey M; Vocadlo, David J; Mark, Brian L

Stubbs, Keith A; Bacik, John-Paul; Perley-Robertson, G Evan; Whitworth, Garrett E; Gloster, Tracey M; Vocadlo, David J; Mark, Brian L.

Affiliation

Stubbs KA; School of Chemistry and Biochemistry, University of Western Australia, 35 Stirling Highway, Crawley, WA 6009 (Australia). keith.stubbs@uwa.edu.au.

Chembiochem ; 14(15): 1973-81, 2013 Oct 11.

Article in En | MEDLINE | ID: mdl-24009110

Subject(s)

Anti-Bacterial Agents/pharmacology; Drug Discovery; Enzyme Inhibitors/pharmacology; Gram-Negative Bacteria/drug effects; Gram-Negative Bacteria/enzymology; Hexosaminidases/antagonists & inhibitors; beta-Lactams/pharmacology; Hexosaminidases/chemistry; Hexosaminidases/metabolism; Humans; Microbial Sensitivity Tests; Models, Molecular; Peptidoglycan/metabolism; Protein Conformation

Key words

carbohydrates; enzymes; inhibitors; selectivity; synthesis

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Full text: 1 Database: MEDLINE Main subject: Beta-Lactams / Enzyme Inhibitors / Drug Discovery / Gram-Negative Bacteria / Hexosaminidases / Anti-Bacterial Agents Limits: Humans Language: En Journal: Chembiochem Journal subject: BIOQUIMICA Year: 2013 Type: Article

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