Dose-dependent metabolic disposition of hydroxytyrosol and formation of mercapturates in rats.

Kotronoulas, Aristotelis; Pizarro, Nieves; Serra, Aida; Robledo, Patricia; Joglar, Jesús; Rubió, Laura; Hernaéz, Alvaro; Tormos, Carmen; Motilva, Ma José; Fitó, Montserrat; Covas, Maria-Isabel; Solà, Rosa; Farré, Magí; Saez, Guillermo; de la Torre, Rafael

Kotronoulas, Aristotelis; Pizarro, Nieves; Serra, Aida; Robledo, Patricia; Joglar, Jesús; Rubió, Laura; Hernaéz, Alvaro; Tormos, Carmen; Motilva, Ma José; Fitó, Montserrat; Covas, Maria-Isabel; Solà, Rosa; Farré, Magí; Saez, Guillermo; de la Torre, Rafael.

Affiliation

Kotronoulas A; Human Pharmacology and Clinical Neurosciences Research Group, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain(1).

Pharmacol Res ; 77: 47-56, 2013 Nov.

Article in En | MEDLINE | ID: mdl-24044986

Subject(s)

Acetylcysteine/metabolism; Antioxidants/metabolism; Antioxidants/pharmacokinetics; Phenylethyl Alcohol/analogs & derivatives; Polyphenols/pharmacokinetics; Acetylcysteine/urine; Animals; Antioxidants/toxicity; Dose-Response Relationship, Drug; Female; Glutathione/urine; Glutathione Disulfide/urine; Male; Phenylethyl Alcohol/metabolism; Phenylethyl Alcohol/pharmacokinetics; Phenylethyl Alcohol/toxicity; Phenylethyl Alcohol/urine; Polyphenols/chemical synthesis; Polyphenols/toxicity; Polyphenols/urine; Rats

Key words

Gluc; Glutathione; HOPhPr; HT; HT-NAC; HTAc; HVAlc; Hydroxytyrosol metabolism; Mercapturate adducts; N-acetyl-5-S-cysteinyl hydroxytyrosol; Oxidative damage; Polyphenols; Sulf; glucuronide; homovanillyl alcohol; hydroxyphenylpropanol; hydroxytyrosol; hydroxytyrosol acetate; sulfate

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Full text: 1 Database: MEDLINE Main subject: Phenylethyl Alcohol / Acetylcysteine / Polyphenols / Antioxidants Limits: Animals Language: En Journal: Pharmacol Res Journal subject: FARMACOLOGIA Year: 2013 Type: Article

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